In diesem Artikel erfahren wir, dass Antibiotikaresistenz ein ernstes Problem ist und wir Wege finden müssen, sie zu bekämpfen. Glücklicherweise hat ein bestimmtes Bakterium das Potenzial, mehr Antibiotikaresistenz zu entwickeln, aber es scheint vorerst kein großes Problem zu sein, da das Bakterium durch die Verwendung von E. coli ET12567 (pUZ8002) als Konjugat in einen antibiotikaempfindlichen Stamm umgewandelt werden kann Spender.
E. coli ET12567 (pUZ8002) wurde als ehelicher Spender in vielen anderen Bakterien verwendet, die bereits gegen Antibiotika resistent sind. Einige dieser Bakterien umfassen: Yersinia pestis, Francisella tularensis und Salmonella enterica serovar Typhimurium. Die Mutationen, die in das Genom von E. coli ET12567 über den konjugierten Transferprozess eingeführt wurden, haben es zu einem hervorragenden Kandidaten für die Entwicklung neuer Antibiotika gemacht.
Die Forscher konnten pUZ8002 verwenden, um eine neue Familie von Antibiotika zu entwickeln, die Mechanismen enthalten, die in bestehenden Medikamenten nicht zu finden sind. Diese neuartigen Mechanismen machen diese Verbindungsklasse besonders nützlich gegen Krankheitserreger, die bestehenden Antibiotika widerstehen, weil sie Resistenzmechanismen entwickelt haben, die sie daran hindern
Woher kamen die Bakterien?
Das zur Herstellung von Antibiotika verwendete Bakterium E. coli kommt in der Umwelt und auf vielen verschiedenen Arten von Lebensmitteln vor. Eine erfolgreiche Transformation von E. coli in einen antibiotikaproduzierenden Stamm wurde jedoch von Forschern der University of Texas in Austin erreicht.
Das Projekt begann mit der Untersuchung von Umweltbakterien, die Antibiotika produzieren. Nachdem die für die Antibiotikaproduktion verantwortlichen Gene identifiziert worden waren, transformierten die Forscher E. coli mit diesen Genen. Das Endergebnis: ein Stamm von E. coli, der in der Lage war, ein Antibiotikum namens Teixobactin zu produzieren.
Der Erfolg dieser Transformation unterstreicht die Leistungsfähigkeit der Geneditierung und eröffnet aufregende neue Möglichkeiten für die Entwicklung von Antibiotika in der Zukunft . Diese Forschung könnte auch in Entwicklungsländern Anwendung finden, in denen Antibiotika knapp oder teuer sind.
Blog-Abschnitt: Was sind die Auswirkungen dieser Forschung?
Die Entwicklung dieses E. coli-Stammes könnte zu neuen Wegen zur Herstellung von Antibiotika führen, ohne dass teure oder schwer zu beschaffende Inhaltsstoffe erforderlich sind. Darüber hinaus zeigt diese Studie das Potenzial der Geneditierung zur Schaffung neuartiger Bakterienstämme, die in der Lage sind, wichtige medizinische Produkte herzustellen.
Insgesamt ist diese Forschung ein großer Fortschritt in dem Bemühen, wirksamere Antibiotika zu entwickeln und neue Behandlungsmöglichkeiten zu eröffnen
Was sind Antibiotika?
Antibiotika sind eine Art von Medikamenten zur Behandlung von Infektionen. Sie wirken, indem sie die Bakterien abtöten, die die Infektion verursachen. Antibiotika können von verschiedenen Bakterienarten produziert werden, aber alle wirken auf die gleiche Weise.
Wie werden Antibiotika hergestellt?
Es gibt mehrere Möglichkeiten, wie Antibiotika hergestellt werden können, aber die gebräuchlichste Methode ist die Züchtung eines Wildtyp- (oder „natürlichen“) Bakteriums in einem Labor. Das Bakterium wird in einem Nährmedium gezüchtet und dann einem antibiotischen Molekül ausgesetzt. Wenn das Antibiotikum das Bakterium abtötet, kann es extrahiert und zur Behandlung von Infektionen eingesetzt werden.
Wie wirken Antibiotika?
Antibiotika wirken, indem sie die Funktionsfähigkeit der Bakterien beeinträchtigen. Dadurch sterben die Bakterien schnell ab, wodurch die Infektion in der Regel geheilt wird.
Wie wirken Antibiotika?
Eine erfolgreiche Transformation von Antibiotika, die von einem gramnegativen Wildtyp-Bakterium, E. coli, produziert werden, veranschaulicht den Prozess, durch den Antibiotika hergestellt werden.
- Antibiotika sind natürliche Substanzen, die schädliche Mikroorganismen abtöten.
- Um ein Antibiotikum herzustellen, müssen Wissenschaftler zunächst die spezifische Krankheit oder Infektion identifizieren, die sie behandeln möchten, und dann die Bakterien isolieren, die dafür verantwortlich sind.
- Sobald die Bakterien isoliert sind, können Forscher damit beginnen, ihr Genom zu untersuchen, um Gene zu identifizieren, die für Proteine kodieren, die das Bakterienwachstum fördern.
- Sie können auch versuchen, diese Gene in andere Bakterien zu kopieren, um ein eigenes Antibiotikum herzustellen. Letztendlich wurden durch diesen Prozess Antibiotika wie Penicillin entwickelt.
Was waren die bioaktiven Moleküle, die sie geschaffen haben?
Die von den Wildtypbakterien erzeugten bioaktiven Moleküle wurden durch die Umwandlung von Acetat in Butyrat und Propionat hergestellt. Von diesen Molekülen ist bekannt, dass sie antibiotische Eigenschaften haben. Was waren die Abnahmen der Zellgröße? Die starke Abnahme der Zellgröße könnte auf eine Abnahme der Produktion von Zellenergie (ATP) oder den tatsächlichen Tod der Zelle zurückzuführen sein. Wenn die Bakterienzellen absterben, würde das erklären, warum keine Glucose mehr in die Zellen aufgenommen wird .
Was haben sie getan, um herauszufinden, welche Gene wichtig sind? Sie untersuchten alle Gene, die am Acetatstoffwechsel beteiligt waren, und betrachteten dann alle Gene, deren Expression sich während des Wachstums mutierter Bakterien veränderte.
Was ist ein Asymmetrie-Gen? Ein Antisense-Oligonukleotid bindet an eine DNA-Sequenz, die eine andere Orientierung hat als die Antisense-Sequenz. Wenn diese beiden Sequenzen aneinander binden, blockieren sie die Transkription, indem sie die Transkription hemmen
Wo würden sie in der Natur zu finden sein?
Gramnegative Bakterien sind in der Natur allgegenwärtig und können an einer Vielzahl von Orten gefunden werden, einschließlich des menschlichen Darms und Bodens. Diese Bakterien produzieren Antibiotika als Abwehr gegen andere Mikroben, was sie zu attraktiven Zielen für die Entwicklung neuer Antibiotika macht . Antibiotika können auch synthetisch hergestellt werden, was jedoch nicht ideal ist, da Bakterien schnell Resistenzen gegen Antibiotika entwickeln. Die „bug-busting“-Eigenschaften synthetischer Antibiotika werden als Antimykotikum in der pharmazeutischen Industrie und in der Landwirtschaft eingesetzt.
ET12567 (pUZ8002) Escherichia coli Strains |
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| S0052 | Lifescience Market | 100 ul | 438 EUR |
pUZ8002 |
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| PVT12448 | Lifescience Market | 2 ug | 843.6 EUR |
T1 Escherichia coli Strains |
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| S0048 | Lifescience Market | 100 ul | 438 EUR |
TG1 Escherichia coli Strains |
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| S0026 | Lifescience Market | 100 ul | 438 EUR |
DB3.1 Escherichia coli Strains |
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| S0043 | Lifescience Market | 100 ul | 438 EUR |
SURE Escherichia coli Strains |
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| S0041 | Lifescience Market | 100 ul | 438 EUR |
BL21 Escherichia coli Strains |
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| S0053 | Lifescience Market | 100 ul | 438 EUR |
K802 Escherichia coli Strains |
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| S0089 | Lifescience Market | 100 ul | 438 EUR |
HB101 Escherichia coli Strains |
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| S0031 | Lifescience Market | 100 ul | 438 EUR |
DH10B Escherichia coli Strains |
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| S0032 | Lifescience Market | 100 ul | 438 EUR |
Stbl2 Escherichia coli Strains |
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| S0034 | Lifescience Market | 100 ul | 438 EUR |
Stbl3 Escherichia coli Strains |
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| S0035 | Lifescience Market | 100 ul | 438 EUR |
JM110 Escherichia coli Strains |
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| S0037 | Lifescience Market | 100 ul | 438 EUR |
JM108 Escherichia coli Strains |
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| S0105 | Lifescience Market | 100 ul | 438 EUR |
Top10F Escherichia coli Strains |
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| S0024 | Lifescience Market | 100 ul | 438 EUR |
BJ5183 Escherichia coli Strains |
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| S0036 | Lifescience Market | 100 ul | 438 EUR |
ER2566 Escherichia coli Strains |
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| S0039 | Lifescience Market | 100 ul | 438 EUR |
TransB Escherichia coli Strains |
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| S0045 | Lifescience Market | 100 ul | 438 EUR |
MC1061 Escherichia coli Strains |
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| S0047 | Lifescience Market | 100 ul | 438 EUR |
EPI300 Escherichia coli Strains |
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| S0050 | Lifescience Market | 100 ul | 438 EUR |
EPI400 Escherichia coli Strains |
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| S0087 | Lifescience Market | 100 ul | 438 EUR |
HB2151 Escherichia coli Strains |
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| S0122 | Lifescience Market | 100 ul | 438 EUR |
DH10Bac Escherichia coli Strains |
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| S0033 | Lifescience Market | 100 ul | 438 EUR |
BW25113 Escherichia coli Strains |
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| S0051 | Lifescience Market | 100 ul | 438 EUR |
Trans110 Escherichia coli Strains |
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| S0046 | Lifescience Market | 100 ul | 438 EUR |
JM109 (DE3) Escherichia coli Strains |
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| S0025 | Lifescience Market | 100 ul | 438 EUR |
M15 (pREP4) Escherichia coli Strains |
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| S0027 | Lifescience Market | 100 ul | 438 EUR |
Tuner (DE3) Escherichia coli Strains |
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| S0040 | Lifescience Market | 100 ul | 438 EUR |
HT115 (DE3) Escherichia coli Strains |
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| S0106 | Lifescience Market | 100 ul | 438 EUR |
XL1-Blue Escherichia coli Strains |
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| S0028 | Lifescience Market | 100 ul | 438 EUR |
XL2-Blue Escherichia coli Strains |
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| S0103 | Lifescience Market | 100 ul | 438 EUR |
BL21/ pREP4 Escherichia coli Strains |
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| S0123 | Lifescience Market | 100 ul | 438 EUR |
XL10-Gold Escherichia coli Strains |
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| S0029 | Lifescience Market | 100 ul | 438 EUR |
SM10 位pir Escherichia coli Strains |
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| S0049 | Lifescience Market | 100 ul | 438 EUR |
HT115 (DE3) -2 Escherichia coli Strains |
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| S0115 | Lifescience Market | 100 ul | 438 EUR |
K-12 MG1655 Escherichia coli Strains |
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| S0042 | Lifescience Market | 100 ul | 438 EUR |
Origami B (DE3) Escherichia coli Strains |
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| S0019 | Lifescience Market | 100 ul | 438 EUR |
Origami 2 (DE3) Escherichia coli Strains |
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| S0021 | Lifescience Market | 100 ul | 438 EUR |
BL21 (DE3) / pREP4 Escherichia coli Strains |
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| S0124 | Lifescience Market | 100 ul | 438 EUR |
Tuner (DE3) pLysS Escherichia coli Strains |
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| S0095 | Lifescience Market | 100 ul | 438 EUR |
BL21 CodonPlus (DE3) Escherichia coli Strains |
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| S0054 | Lifescience Market | 100 ul | 438 EUR |
BJ5183/ pAdEasy-1 Escherichia coli Strains |
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| S0125 | Lifescience Market | 100 ul | 438 EUR |
XL2 blue MRF'-1 Escherichia coli Strains |
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| S0030 | Lifescience Market | 100 ul | 438 EUR |
S17-1 位pir Escherichia coli Strains |
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| S0038 | Lifescience Market | 100 ul | 438 EUR |
XL2 Blue MRF'-2 Escherichia coli Strains |
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| S0044 | Lifescience Market | 100 ul | 438 EUR |
DH5伪 位pir Escherichia coli Strains |
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| S0120 | Lifescience Market | 100 ul | 438 EUR |
ArcticExpress (DE3) RP Escherichia coli Strains |
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| S0023 | Lifescience Market | 100 ul | 438 EUR |
Tac-mCherry/ MG1655 Escherichia coli Strains |
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| S0114 | Lifescience Market | 100 ul | 438 EUR |
Origami 2 (DE3) pLysS Escherichia coli Strains |
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| S0055 | Lifescience Market | 100 ul | 438 EUR |
Origami B (DE3) pLysS Escherichia coli Strains |
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| S0099 | Lifescience Market | 100 ul | 438 EUR |
Rosetta-gami-B (DE3) Escherichia coli Strains |
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| S0020 | Lifescience Market | 100 ul | 438 EUR |
Rosetta-gami (DE3) pLysS Escherichia coli Strains |
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| S0022 | Lifescience Market | 100 ul | 438 EUR |
genesig Easy kit for Escherichia coli (all strains) |
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| Z-Path-E.coli_spp-EASY | Novacyt Group | 50 tests | 410 EUR |
ViPrimePLUS Escherichia coli (all strains) qPCR Kit, 150rxns |
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| QM2025 | Vivantis | each | Ask for price |
Recombinant Escherichia coli cysZ Protein (aa 1-253) (strain S88 / ExPEC) |
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| VAng-Lsx02277-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli dapB Protein (aa 1-273) (strain S88 / ExPEC) |
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| VAng-Lsx02308-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | 4728 EUR |
Recombinant Escherichia coli dapB Protein (aa 1-273) (strain S88 / ExPEC) |
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| VAng-Lsx02308-500gEcoli | Creative Biolabs | 500 µg (E. coli) | 3342 EUR |
Recombinant Escherichia coli dapB Protein (aa 1-273) (strain S88 / ExPEC) |
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| VAng-Lsx02308-50gEcoli | Creative Biolabs | 50 µg (E. coli) | 2287.2 EUR |
Recombinant Escherichia coli dapD Protein (aa 1-274) (strain S88 / ExPEC) |
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| VAng-Lsx02325-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | 4728 EUR |
Recombinant Escherichia coli dapD Protein (aa 1-274) (strain S88 / ExPEC) |
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| VAng-Lsx02325-500gEcoli | Creative Biolabs | 500 µg (E. coli) | 3360 EUR |
Recombinant Escherichia coli dapD Protein (aa 1-274) (strain S88 / ExPEC) |
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| VAng-Lsx02325-50gEcoli | Creative Biolabs | 50 µg (E. coli) | 2287.2 EUR |
Recombinant Escherichia coli mdtI Protein (aa 1-109) (strain S88 / ExPEC) |
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| VAng-Lsx02501-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli ubiB Protein (aa 1-546) (strain S88 / ExPEC) |
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| VAng-Lsx02680-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli yqhA Protein (aa 1-164) (strain S88 / ExPEC) |
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| VAng-Lsx02999-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli zntB Protein (aa 1-327) (strain S88 / ExPEC) |
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| VAng-Lsx03035-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli zupT Protein (aa 1-257) (strain S88 / ExPEC) |
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| VAng-Lsx03052-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli aaeX Protein (aa 1-67) (strain S88 / ExPEC) |
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| VAng-Lsx02146-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli (strain 55989 / EAEC) Agmatinase |
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| MBS1132181-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | 1180 EUR |
Recombinant Escherichia coli (strain 55989 / EAEC) Agmatinase |
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| MBS1132181-002mgEColi | MyBiosource | 0.02mg(E-Coli) | 375 EUR |
Recombinant Escherichia coli (strain 55989 / EAEC) Agmatinase |
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| MBS1132181-002mgYeast | MyBiosource | 0.02mg(Yeast) | 970 EUR |
Recombinant Escherichia coli (strain 55989 / EAEC) Agmatinase |
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| MBS1132181-01mgEColi | MyBiosource | 0.1mg(E-Coli) | 635 EUR |
Recombinant Escherichia coli (strain 55989 / EAEC) Agmatinase |
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| MBS1132181-01mgYeast | MyBiosource | 0.1mg(Yeast) | 1135 EUR |
LPS from Escherichia coli K12 strain LCD25 |
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| 314 | List Biological Laboratories | 1mg | 200 EUR |
Recombinant Escherichia coli (strain K12) LexA repressor |
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| MBS1108189-002mgEColi | MyBiosource | 0.02mg(E-Coli) | 375 EUR |
Recombinant Escherichia coli (strain K12) LexA repressor |
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| MBS1108189-01mgEColi | MyBiosource | 0.1mg(E-Coli) | 635 EUR |
Recombinant Escherichia coli (strain K12) LexA repressor |
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| MBS1108189-1mgEColi | MyBiosource | 1mg(E-Coli) | 1925 EUR |
Recombinant Escherichia coli (strain K12) LexA repressor |
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| MBS1108189-5x1mgEColi | MyBiosource | 5x1mg(E-Coli) | 8405 EUR |
Recombinant Escherichia coli (strain K12) Transketolase 1 |
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| MBS1185327-002mgEColi | MyBiosource | 0.02mg(E-Coli) | 375 EUR |
Recombinant Escherichia coli (strain K12) Transketolase 1 |
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| MBS1185327-01mgEColi | MyBiosource | 0.1mg(E-Coli) | 635 EUR |
Recombinant Escherichia coli (strain K12) Transketolase 1 |
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| MBS1185327-1mgEColi | MyBiosource | 1mg(E-Coli) | 1925 EUR |
Recombinant Escherichia coli (strain K12) Transketolase 1 |
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| MBS1185327-5x1mgEColi | MyBiosource | 5x1mg(E-Coli) | 8405 EUR |
Recombinant Escherichia coli (strain K12) Transketolase 1 |
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| MBS9420965-002mg | MyBiosource | 0.02mg | 460 EUR |
Recombinant Escherichia coli (strain K12) Transketolase 1 |
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| MBS9420965-01mg | MyBiosource | 0.1mg | 795 EUR |
Recombinant Escherichia coli (strain K12) Transketolase 1 |
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| MBS9420965-1mg | MyBiosource | 1mg | 2525 EUR |
Recombinant Escherichia coli (strain K12) Transketolase 1 |
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| MBS9420965-5x1mg | MyBiosource | 5x1mg | 11205 EUR |
Recombinant Escherichia coli (strain K12) Lipid kinase YegS |
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| MBS1121861-002mgEColi | MyBiosource | 0.02mg(E-Coli) | 375 EUR |
Recombinant Escherichia coli (strain K12) Lipid kinase YegS |
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| MBS1121861-01mgEColi | MyBiosource | 0.1mg(E-Coli) | 635 EUR |
Recombinant Escherichia coli (strain K12) Lipid kinase YegS |
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| MBS1121861-1mgEColi | MyBiosource | 1mg(E-Coli) | 1925 EUR |
Recombinant Escherichia coli (strain K12) Lipid kinase YegS |
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| MBS1121861-5x1mgEColi | MyBiosource | 5x1mg(E-Coli) | 8405 EUR |
Recombinant Escherichia coli (strain K12) Cytosine deaminase |
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| MBS1076859-002mgEColi | MyBiosource | 0.02mg(E-Coli) | 375 EUR |
Recombinant Escherichia coli (strain K12) Cytosine deaminase |
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| MBS1076859-002mgYeast | MyBiosource | 0.02mg(Yeast) | 420 EUR |
Recombinant Escherichia coli (strain K12) Cytosine deaminase |
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| MBS1076859-01mgEColi | MyBiosource | 0.1mg(E-Coli) | 635 EUR |
Recombinant Escherichia coli (strain K12) Cytosine deaminase |
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| MBS1076859-01mgYeast | MyBiosource | 0.1mg(Yeast) | 695 EUR |
Recombinant Escherichia coli (strain K12) Cytosine deaminase |
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| MBS1076859-05mgYeast | MyBiosource | 0.5mg(Yeast) | 1505 EUR |
Recombinant Escherichia coli (strain K12) Cytosine deaminase |
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| MBS9420963-002mg | MyBiosource | 0.02mg | 460 EUR |
Recombinant Escherichia coli (strain K12) Cytosine deaminase |
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| MBS9420963-01mg | MyBiosource | 0.1mg | 795 EUR |
Recombinant Escherichia coli (strain K12) Cytosine deaminase |
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| MBS9420963-1mg | MyBiosource | 1mg | 2525 EUR |
Recombinant Escherichia coli (strain K12) Cytosine deaminase |
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| MBS9420963-5x1mg | MyBiosource | 5x1mg | 11205 EUR |
Recombinant Escherichia coli (strain K12) Cytosine deaminase |
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| MBS9422637-002mg | MyBiosource | 0.02mg | 505 EUR |
Recombinant Escherichia coli (strain K12) Cytosine deaminase |
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| MBS9422637-01mg | MyBiosource | 0.1mg | 895 EUR |
Recombinant Escherichia coli (strain K12) Cytosine deaminase |
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| MBS9422637-05mg | MyBiosource | 0.5mg | 1975 EUR |
Recombinant Escherichia coli (strain K12) Cytosine deaminase |
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| MBS9422637-5x05mg | MyBiosource | 5x0.5mg | 8735 EUR |
Recombinant Escherichia coli (strain K12) Adenosine deaminase |
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| MBS1160202-002mgEColi | MyBiosource | 0.02mg(E-Coli) | 375 EUR |
Recombinant Escherichia coli (strain K12) Adenosine deaminase |
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| MBS1160202-01mgEColi | MyBiosource | 0.1mg(E-Coli) | 635 EUR |
Recombinant Escherichia coli (strain K12) Adenosine deaminase |
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| MBS1160202-1mgEColi | MyBiosource | 1mg(E-Coli) | 1925 EUR |
Recombinant Escherichia coli (strain K12) Adenosine deaminase |
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| MBS1160202-5x1mgEColi | MyBiosource | 5x1mg(E-Coli) | 8405 EUR |
Recombinant Escherichia coli (strain K12) Adenosine deaminase |
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| MBS9419968-002mg | MyBiosource | 0.02mg | 460 EUR |
Recombinant Escherichia coli (strain K12) Adenosine deaminase |
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| MBS9419968-01mg | MyBiosource | 0.1mg | 795 EUR |
Recombinant Escherichia coli (strain K12) Adenosine deaminase |
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| MBS9419968-1mg | MyBiosource | 1mg | 2525 EUR |
Recombinant Escherichia coli (strain K12) Adenosine deaminase |
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| MBS9419968-5x1mg | MyBiosource | 5x1mg | 11205 EUR |
Recombinant Escherichia coli (strain K12) Elongation factor P |
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| MBS1043992-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | 1105 EUR |
Recombinant Escherichia coli (strain K12) Elongation factor P |
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| MBS1043992-002mgEColi | MyBiosource | 0.02mg(E-Coli) | 375 EUR |
Recombinant Escherichia coli (strain K12) Elongation factor P |
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| MBS1043992-002mgYeast | MyBiosource | 0.02mg(Yeast) | 420 EUR |
Recombinant Escherichia coli (strain K12) Elongation factor P |
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| MBS1043992-01mgEColi | MyBiosource | 0.1mg(E-Coli) | 640 EUR |
Recombinant Escherichia coli (strain K12) Elongation factor P |
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| MBS1043992-01mgYeast | MyBiosource | 0.1mg(Yeast) | 695 EUR |
Recombinant Escherichia coli cobS Protein (aa 1-247) (strain 55989 / EAEC) |
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| VAng-Lsx02219-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli crcB Protein (aa 1-127) (strain 55989 / EAEC) |
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| VAng-Lsx02243-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli cysZ Protein (aa 1-253) (strain 55989 / EAEC) |
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| VAng-Lsx02274-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli dapA Protein (aa 1-292) (strain 55989 / EAEC) |
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| VAng-Lsx02294-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | 4876.8 EUR |
Recombinant Escherichia coli dapA Protein (aa 1-292) (strain 55989 / EAEC) |
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| VAng-Lsx02294-500gEcoli | Creative Biolabs | 500 µg (E. coli) | 3442.8 EUR |
Recombinant Escherichia coli dapA Protein (aa 1-292) (strain 55989 / EAEC) |
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| VAng-Lsx02294-50gEcoli | Creative Biolabs | 50 µg (E. coli) | 2353.2 EUR |
Recombinant Escherichia coli dapB Protein (aa 1-273) (strain 55989 / EAEC) |
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| VAng-Lsx02306-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | 4728 EUR |
Recombinant Escherichia coli dapB Protein (aa 1-273) (strain 55989 / EAEC) |
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| VAng-Lsx02306-500gEcoli | Creative Biolabs | 500 µg (E. coli) | 3342 EUR |
Recombinant Escherichia coli dapB Protein (aa 1-273) (strain 55989 / EAEC) |
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| VAng-Lsx02306-50gEcoli | Creative Biolabs | 50 µg (E. coli) | 2287.2 EUR |
Recombinant Escherichia coli mscL Protein (aa 1-136) (strain 55989 / EAEC) |
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| VAng-Lsx02519-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli psiE Protein (aa 1-136) (strain 55989 / EAEC) |
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| VAng-Lsx02582-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli rsxE Protein (aa 1-231) (strain 55989 / EAEC) |
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| VAng-Lsx02615-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli ubiB Protein (aa 1-546) (strain 55989 / EAEC) |
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| VAng-Lsx02677-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli uspB Protein (aa 1-111) (strain 55989 / EAEC) |
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| VAng-Lsx02697-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli yciB Protein (aa 1-179) (strain 55989 / EAEC) |
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| VAng-Lsx02755-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli yciC Protein (aa 1-247) (strain 55989 / EAEC) |
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| VAng-Lsx02764-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli ycjF Protein (aa 1-353) (strain 55989 / EAEC) |
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| VAng-Lsx02775-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli yeaL Protein (aa 1-148) (strain 55989 / EAEC) |
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| VAng-Lsx02795-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli yfbV Protein (aa 1-151) (strain 55989 / EAEC) |
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| VAng-Lsx02828-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli yihY Protein (aa 1-290) (strain 55989 / EAEC) |
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| VAng-Lsx02905-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli ynfA Protein (aa 1-108) (strain 55989 / EAEC) |
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| VAng-Lsx02954-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli yobD Protein (aa 1-152) (strain 55989 / EAEC) |
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| VAng-Lsx02964-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli yohJ Protein (aa 1-132) (strain 55989 / EAEC) |
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| VAng-Lsx02974-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli zntB Protein (aa 1-327) (strain 55989 / EAEC) |
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| VAng-Lsx03030-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli zupT Protein (aa 1-257) (strain 55989 / EAEC) |
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| VAng-Lsx03048-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli aaeX Protein (aa 1-67) (strain 55989 / EAEC) |
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| VAng-Lsx02143-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli dapB Protein (aa 1-273) (strain 536 / UPEC) |
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| VAng-Lsx02315-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli dapD Protein (aa 1-274) (strain 536 / UPEC) |
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| VAng-Lsx02332-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | 4728 EUR |
Recombinant Escherichia coli dapD Protein (aa 1-274) (strain 536 / UPEC) |
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| VAng-Lsx02332-500gEcoli | Creative Biolabs | 500 µg (E. coli) | 3360 EUR |
Recombinant Escherichia coli dapD Protein (aa 1-274) (strain 536 / UPEC) |
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| VAng-Lsx02332-50gEcoli | Creative Biolabs | 50 µg (E. coli) | 2287.2 EUR |
Recombinant Escherichia coli lgt Protein (aa 1-291) (strain HS) |
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| VAng-Lsx02463-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli (strain K12) Outer membrane protein C |
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| MBS1259203-002mgEColi | MyBiosource | 0.02mg(E-Coli) | 375 EUR |
Recombinant Escherichia coli (strain K12) Outer membrane protein C |
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| MBS1259203-01mgEColi | MyBiosource | 0.1mg(E-Coli) | 635 EUR |
Recombinant Escherichia coli (strain K12) Outer membrane protein C |
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| MBS1259203-1mgEColi | MyBiosource | 1mg(E-Coli) | 1925 EUR |
Recombinant Escherichia coli (strain K12) Outer membrane protein C |
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| MBS1259203-5x1mgEColi | MyBiosource | 5x1mg(E-Coli) | 8405 EUR |
Recombinant Escherichia coli cbrB Protein (aa 1-157) (strain HS) |
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| VAng-Lsx02189-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli cls Protein (aa 1-486) (strain K12) |
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| VAng-Lsx02206-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli crcB Protein (aa 1-127) (strain HS) |
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| VAng-Lsx02238-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli cysZ Protein (aa 1-253) (strain HS) |
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| VAng-Lsx02273-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli dapA Protein (aa 1-292) (strain HS) |
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| VAng-Lsx02292-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | 4876.8 EUR |
Recombinant Escherichia coli dapA Protein (aa 1-292) (strain HS) |
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| VAng-Lsx02292-500gEcoli | Creative Biolabs | 500 µg (E. coli) | 3442.8 EUR |
Recombinant Escherichia coli dapA Protein (aa 1-292) (strain HS) |
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| VAng-Lsx02292-50gEcoli | Creative Biolabs | 50 µg (E. coli) | 2353.2 EUR |
Recombinant Escherichia coli dapD Protein (aa 1-274) (strain HS) |
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| VAng-Lsx02328-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | 4728 EUR |
Recombinant Escherichia coli dapD Protein (aa 1-274) (strain HS) |
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| VAng-Lsx02328-500gEcoli | Creative Biolabs | 500 µg (E. coli) | 3360 EUR |
Recombinant Escherichia coli dapD Protein (aa 1-274) (strain HS) |
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| VAng-Lsx02328-50gEcoli | Creative Biolabs | 50 µg (E. coli) | 2287.2 EUR |
Recombinant Escherichia coli lgt Protein (aa 1-291) (strain K12) |
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| VAng-Lsx02460-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli mdtJ Protein (aa 1-121) (strain HS) |
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| VAng-Lsx02504-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli mscL Protein (aa 1-136) (strain HS) |
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| VAng-Lsx02517-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli psiE Protein (aa 1-136) (strain HS) |
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| VAng-Lsx02575-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli ubiB Protein (aa 1-546) (strain HS) |
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| VAng-Lsx02684-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli uspB Protein (aa 1-111) (strain HS) |
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| VAng-Lsx02693-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli yeaL Protein (aa 1-148) (strain HS) |
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| VAng-Lsx02797-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli yfbV Protein (aa 1-151) (strain HS) |
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| VAng-Lsx02830-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli yqhA Protein (aa 1-164) (strain HS) |
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| VAng-Lsx02998-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli zntB Protein (aa 1-327) (strain HS) |
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| VAng-Lsx03037-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli zupT Protein (aa 1-257) (strain HS) |
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| VAng-Lsx03043-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli alaE Protein (aa 1-149) (strain K12) |
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| VAng-Lsx02160-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli arcB Protein (aa 1-778) (strain K12) |
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| VAng-Lsx02166-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli ccmC Protein (aa 1-245) (strain K12) |
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| VAng-Lsx02193-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli cls Protein (aa 1-486) (strain IAI1) |
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| VAng-Lsx02207-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli cobS Protein (aa 1-247) (strain K12) |
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| VAng-Lsx02215-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli corA Protein (aa 1-316) (strain K12) |
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| VAng-Lsx02233-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli crcB Protein (aa 1-127) (strain K12) |
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| VAng-Lsx02237-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli cvpA Protein (aa 1-162) (strain K12) |
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| VAng-Lsx02261-100g | Creative Biolabs | 100 µg | 7335.6 EUR |
Recombinant Escherichia coli cvpA Protein (aa 1-162) (strain K12) |
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| VAng-Lsx02261-50g | Creative Biolabs | 50 µg | 4282.8 EUR |
Recombinant Escherichia coli cysZ Protein (aa 1-253) (strain K12) |
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| VAng-Lsx02271-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli dapA Protein (aa 1-292) (strain K12) |
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| VAng-Lsx02299-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | 4876.8 EUR |
Recombinant Escherichia coli dapA Protein (aa 1-292) (strain K12) |
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| VAng-Lsx02299-500gEcoli | Creative Biolabs | 500 µg (E. coli) | 3442.8 EUR |
Recombinant Escherichia coli dapA Protein (aa 1-292) (strain K12) |
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| VAng-Lsx02299-50gEcoli | Creative Biolabs | 50 µg (E. coli) | 2353.2 EUR |
Recombinant Escherichia coli dapB Protein (aa 1-273) (strain K12) |
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| VAng-Lsx02310-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | 4728 EUR |
Recombinant Escherichia coli dapB Protein (aa 1-273) (strain K12) |
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| VAng-Lsx02310-500gEcoli | Creative Biolabs | 500 µg (E. coli) | 3342 EUR |
Recombinant Escherichia coli dapB Protein (aa 1-273) (strain K12) |
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| VAng-Lsx02310-50gEcoli | Creative Biolabs | 50 µg (E. coli) | 2287.2 EUR |
Recombinant Escherichia coli dapD Protein (aa 1-274) (strain K12) |
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| VAng-Lsx02336-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | 4728 EUR |
Recombinant Escherichia coli dapD Protein (aa 1-274) (strain K12) |
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| VAng-Lsx02336-500gEcoli | Creative Biolabs | 500 µg (E. coli) | 3360 EUR |
Recombinant Escherichia coli dapD Protein (aa 1-274) (strain K12) |
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| VAng-Lsx02336-50gEcoli | Creative Biolabs | 50 µg (E. coli) | 2287.2 EUR |
Recombinant Escherichia coli dedA Protein (aa 1-219) (strain K12) |
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| VAng-Lsx02340-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli dppB Protein (aa 1-339) (strain K12) |
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| VAng-Lsx02345-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli dppC Protein (aa 1-300) (strain K12) |
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| VAng-Lsx02348-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli dsbB Protein (aa 1-176) (strain K12) |
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| VAng-Lsx02351-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli exbB Protein (aa 1-244) (strain K12) |
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| VAng-Lsx02368-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli fieF Protein (aa 1-300) (strain K12) |
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| VAng-Lsx02375-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli fliL Protein (aa 1-154) (strain K12) |
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| VAng-Lsx02380-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli focA Protein (aa 1-285) (strain K12) |
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| VAng-Lsx02389-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli ftsX Protein (aa 1-352) (strain K12) |
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| VAng-Lsx02394-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli glpF Protein (aa 1-281) (strain K12) |
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| VAng-Lsx02403-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli gltJ Protein (aa 1-246) (strain K12) |
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| VAng-Lsx02408-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli gltK Protein (aa 1-224) (strain K12) |
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| VAng-Lsx02410-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli hdeD Protein (aa 1-190) (strain K12) |
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| VAng-Lsx02421-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli hisM Protein (aa 1-238) (strain K12) |
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| VAng-Lsx02426-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli malG Protein (aa 1-296) (strain K12) |
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| VAng-Lsx02483-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli marC Protein (aa 1-221) (strain K12) |
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| VAng-Lsx02488-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli mdtI Protein (aa 1-109) (strain K12) |
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| VAng-Lsx02499-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli mdtJ Protein (aa 1-121) (strain K12) |
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| VAng-Lsx02503-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli mreD Protein (aa 1-162) (strain K12) |
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| VAng-Lsx02511-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli mscL Protein (aa 1-136) (strain K12) |
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| VAng-Lsx02515-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli narX Protein (aa 1-598) (strain K12) |
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| VAng-Lsx02531-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli nfrB Protein (aa 1-745) (strain K12) |
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| VAng-Lsx02533-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli nikC Protein (aa 1-277) (strain K12) |
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| VAng-Lsx02537-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli oppC Protein (aa 1-302) (strain K12) |
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| VAng-Lsx02545-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli pgaD Protein (aa 1-137) (strain K12) |
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| VAng-Lsx02549-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli psiE Protein (aa 1-136) (strain K12) |
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| VAng-Lsx02572-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli pspC Protein (aa 1-119) (strain K12) |
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| VAng-Lsx02584-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli rcnA Protein (aa 1-274) (strain K12) |
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| VAng-Lsx02596-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli rhtB Protein (aa 1-206) (strain K12) |
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| VAng-Lsx02602-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli rsxE Protein (aa 1-231) (strain K12) |
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| VAng-Lsx02614-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli sapB Protein (aa 1-321) (strain K12) |
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| VAng-Lsx02621-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli sapC Protein (aa 1-296) (strain K12) |
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| VAng-Lsx02623-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli sbmA Protein (aa 1-406) (strain K12) |
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| VAng-Lsx02625-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli secD Protein (aa 1-615) (strain K12) |
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| VAng-Lsx02628-inquire | Creative Biolabs | inquire | Ask for price |
Recombinant Escherichia coli secE Protein (aa 1-127) (strain K12) |
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| VAng-Lsx02630-inquire | Creative Biolabs | inquire | Ask for price |
Bakteriophage – Ein Virus, das Bakterien infiziert. Es gibt mehrere Mechanismen, die genutzt werden könnten, um Gene in Bakterienzellen zu übertragen: Gezielter Einbau von DNA in Bakteriophagen-DNA, Transformation (bei der einige Bakterien mit einem Plasmid das Phagengen aufnehmen und replizieren können) oder Transduktion (bei der eine nackte DNA-Molekül wird von einem anderen Bakterium aufgenommen und in dessen Genom eingebaut). Bakteriophagen